Calcium-D-glucarate
Detox · Beta-glucuronidase inhibitor
Tier C+
What this is
Rationale is real — gut β-glucuronidase activity does influence reabsorption of conjugated hormones and xenobiotics. But clinical outcome data in humans is thin. Popular in 'estrogen detox' protocols around women's health and hormone rebalancing. Reasonable low-risk adjunct but not a clinical standard.
Mechanism
Metabolite of glucaric acid; inhibits β-glucuronidase — an enzyme produced by gut bacteria that deconjugates glucuronidated compounds (hormones, toxins) in the gut, allowing their reabsorption
Dose & route
500-1500 mg/day PO
Citations
- https://pubmed.ncbi.nlm.nih.gov/11822712/
- https://pubmed.ncbi.nlm.nih.gov/9630523/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6721807/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.