Calcium-D-glucarate
Detox · Beta-glucuronidase inhibitor
Tier C+
Bottom line
Read Off Label grades Calcium-D-glucarate as C+ (5.4/10) based on weak evidence, weak benefit magnitude, and a low-risk safety profile.
Rationale is real — gut β-glucuronidase activity does influence reabsorption of conjugated hormones and xenobiotics.
Studied, labeled, or reported-use context: 500-1500 mg/day PO — OTC; not individualized guidance.
What the evidence says
Rationale is real — gut β-glucuronidase activity does influence reabsorption of conjugated hormones and xenobiotics. But clinical outcome data in humans is thin. Popular in 'estrogen detox' protocols around women's health and hormone rebalancing. Mechanistic evidence exists; clinical outcome evidence is limited and this is not a clinical standard.
Mechanism
Metabolite of glucaric acid; inhibits β-glucuronidase — an enzyme produced by gut bacteria that deconjugates glucuronidated compounds (hormones, toxins) in the gut, allowing their reabsorption
Studied, labeled, or reported dose & route
500-1500 mg/day PO
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Calcium-D-glucarate's effects?
- Read Off Label rates the evidence for Calcium-D-glucarate as Weak and the benefit magnitude as weak, producing an overall grade of C+ (5.4/10). Rationale is real — gut β-glucuronidase activity does influence reabsorption of conjugated hormones and xenobiotics.
- What safety findings are reported for Calcium-D-glucarate?
- Calcium-D-glucarate has a low risk profile in the database. Low (well-tolerated) Legal status: OTC.
- What doses or routes are reported for Calcium-D-glucarate?
- 500-1500 mg/day PO This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Calcium-D-glucarate work?
- Metabolite of glucaric acid; inhibits β-glucuronidase — an enzyme produced by gut bacteria that deconjugates glucuronidated compounds (hormones, toxins) in the gut, allowing their reabsorption
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.