Rankings / Detox

Glutathione (liposomal / IV / S-acetyl)

Detox · Master intracellular antioxidant

Tier B

Reviewed by Read Off Label · Last reviewed · How we grade

peptideantioxidantglutathioneotc
6.4 / 10
Tier B
Ev 4.5 Bn 5 Sf 9

Bottom line

Read Off Label grades Glutathione (liposomal / IV / S-acetyl) as B (6.4/10) based on weak-moderate evidence, variable benefit magnitude, and a low-risk safety profile.

Standard oral glutathione has poor bioavailability (broken down in GI).

Typical use: Liposomal oral 500-1000 mg/day; IV 1000-3000 mg (off-label uses) — OTC (oral forms); off-label IV.

What this is

Standard oral glutathione has poor bioavailability (broken down in GI). Liposomal and S-acetyl glutathione claim better absorption with supporting but not overwhelming data. NAC is usually more cost-effective for raising glutathione. IV glutathione has a robust cottage industry in biohacker clinics with limited controlled evidence beyond acute toxicology indications.

Mechanism

Primary intracellular antioxidant; tripeptide (glutamate-cysteine-glycine); reduced (GSH) and oxidized (GSSG) forms; phase II conjugation (glutathione-S-transferase) for xenobiotic elimination

Dose & route

Liposomal oral 500-1000 mg/day; IV 1000-3000 mg (off-label uses)

Citations

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Common questions

Does Glutathione (liposomal / IV / S-acetyl) work?
Read Off Label rates the evidence for Glutathione (liposomal / IV / S-acetyl) as Weak-Moderate and the benefit magnitude as variable, producing an overall grade of B (6.4/10). Standard oral glutathione has poor bioavailability (broken down in GI).
Is Glutathione (liposomal / IV / S-acetyl) safe?
Glutathione (liposomal / IV / S-acetyl) has a low risk profile in published human data. Legal status: OTC (oral forms); off-label IV (compounded). This is not medical advice — see the disclaimer.
What is the typical dose for Glutathione (liposomal / IV / S-acetyl)?
Liposomal oral 500-1000 mg/day; IV 1000-3000 mg (off-label uses)
How does Glutathione (liposomal / IV / S-acetyl) work?
Primary intracellular antioxidant; tripeptide (glutamate-cysteine-glycine); reduced (GSH) and oxidized (GSSG) forms; phase II conjugation (glutathione-S-transferase) for xenobiotic elimination

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.