Glutathione (liposomal / IV / S-acetyl)
Detox · Master intracellular antioxidant
Tier A-
What this is
Standard oral glutathione has poor bioavailability (broken down in GI). Liposomal and S-acetyl glutathione claim better absorption with supporting but not overwhelming data. NAC is usually more cost-effective for raising glutathione. IV glutathione has a robust cottage industry in biohacker clinics with limited controlled evidence beyond acute toxicology indications.
Mechanism
Primary intracellular antioxidant; tripeptide (glutamate-cysteine-glycine); reduced (GSH) and oxidized (GSSG) forms; phase II conjugation (glutathione-S-transferase) for xenobiotic elimination
Dose & route
Liposomal oral 500-1000 mg/day; IV 1000-3000 mg (off-label uses)
Citations
- https://pubmed.ncbi.nlm.nih.gov/28927026/
- https://pubmed.ncbi.nlm.nih.gov/29145469/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5820806/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.