Glutathione (liposomal / IV / S-acetyl)
Detox · Master intracellular antioxidant
Tier B
Bottom line
Read Off Label grades Glutathione (liposomal / IV / S-acetyl) as B (6.4/10) based on weak-moderate evidence, variable benefit magnitude, and a low-risk safety profile.
Standard oral glutathione has poor bioavailability (broken down in GI).
Studied, labeled, or reported-use context: Liposomal oral 500-1000 mg/day; IV 1000-3000 mg (off-label uses) — OTC (oral forms); off-label IV; not individualized guidance.
What the evidence says
Standard oral glutathione has poor bioavailability (broken down in GI). Liposomal and S-acetyl glutathione claim better absorption with supporting but not overwhelming data. NAC is a different precursor strategy with a distinct evidence and cost profile. IV glutathione has a robust cottage industry in biohacker clinics with limited controlled evidence beyond acute toxicology indications.
Mechanism
Primary intracellular antioxidant; tripeptide (glutamate-cysteine-glycine); reduced (GSH) and oxidized (GSSG) forms; phase II conjugation (glutathione-S-transferase) for xenobiotic elimination
Studied, labeled, or reported dose & route
Liposomal oral 500-1000 mg/day; IV 1000-3000 mg (off-label uses)
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
A link means the source informed this entry; it does not mean every claim on the page comes from that source. If a citation looks wrong or you want a claim re-checked, send a correction.
Common questions
- What does the evidence show about Glutathione (liposomal / IV / S-acetyl)'s effects?
- Read Off Label rates the evidence for Glutathione (liposomal / IV / S-acetyl) as Weak-Moderate and the benefit magnitude as variable, producing an overall grade of B (6.4/10). Standard oral glutathione has poor bioavailability (broken down in GI).
- What safety findings are reported for Glutathione (liposomal / IV / S-acetyl)?
- Glutathione (liposomal / IV / S-acetyl) has a low risk profile in the database. Low (rare sulfur GI issues; IV rare hypersensitivity) Legal status: OTC (oral forms); off-label IV (compounded).
- What doses or routes are reported for Glutathione (liposomal / IV / S-acetyl)?
- Liposomal oral 500-1000 mg/day; IV 1000-3000 mg (off-label uses) This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Glutathione (liposomal / IV / S-acetyl) work?
- Primary intracellular antioxidant; tripeptide (glutamate-cysteine-glycine); reduced (GSH) and oxidized (GSSG) forms; phase II conjugation (glutathione-S-transferase) for xenobiotic elimination
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.