DIM (diindolylmethane) / I3C
Detox · Cruciferous phytochemical
Tier C
What this is
Rationale from estrogen metabolism pathway is solid — 2:16 ratio is a recognized biomarker. Actual disease-endpoint RCT data limited. BR-DIM (bioresponse DIM) with enhanced absorption preferred over unformulated powder. Eat broccoli and related vegetables first; supplement is a concentrated version of same principle.
Mechanism
Dimer of indole-3-carbinol; shifts estrogen metabolism toward the 2-hydroxy (less proliferative) pathway vs 16α-hydroxy (more proliferative); produces the 2-OH:16α-OH ratio shift seen with high cruciferous vegetable intake
Dose & route
100-300 mg/day with fat for absorption
Citations
- https://pubmed.ncbi.nlm.nih.gov/19901116/
- https://pubmed.ncbi.nlm.nih.gov/15798098/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7461007/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.