Read Off Label rates the evidence for Luteolin as Preclinical and the benefit magnitude as low, producing an overall grade of C (4.8/10). Frequently cited alongside fisetin and quercetin in the senolytic-stack literature but with much thinner human data than either.

Luteolin has a low risk profile in published human data. Legal status: OTC. This is not medical advice — see the disclaimer.

Rankings / Longevity — Senolytics & Polyphenols

Luteolin

Longevity · Flavonoid (senolytic-adjacent)

Tier C

Reviewed by Read Off Label · Last reviewed Jun 8, 2026 · How we grade

senolyticanti-inflammatoryotc

4.8 / 10

Tier C

Ev 2 Bn 2 Sf 9

Bottom line

Read Off Label grades Luteolin as C (4.8/10) based on preclinical evidence, low benefit magnitude, and a low-risk safety profile.

Frequently cited alongside fisetin and quercetin in the senolytic-stack literature but with much thinner human data than either.

Typical use: 100-300 mg/day; often combined with quercetin/apigenin for senolytic stacks; food sources include parsley, celery,… — OTC.

What this is

Frequently cited alongside fisetin and quercetin in the senolytic-stack literature but with much thinner human data than either. Reasonable adjunct to a D+Q-style protocol if tolerated; not standalone evidence. Bioavailability is poor — liposomal/phytosomal formulations help.

Mechanism

3',4',5,7-tetrahydroxyflavone; PI3K/AKT/mTOR inhibition; NF-kB suppression; tested as a senolytic adjunct to dasatinib + quercetin; mast-cell stabilizer; weak MAO-B inhibitor

Dose & route

100-300 mg/day; often combined with quercetin/apigenin for senolytic stacks; food sources include parsley, celery, artichoke

Citations

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Common questions

Does Luteolin work?: Read Off Label rates the evidence for Luteolin as Preclinical and the benefit magnitude as low, producing an overall grade of C (4.8/10). Frequently cited alongside fisetin and quercetin in the senolytic-stack literature but with much thinner human data than either.
Is Luteolin safe?: Luteolin has a low risk profile in published human data. Legal status: OTC. This is not medical advice — see the disclaimer.
What is the typical dose for Luteolin?: 100-300 mg/day; often combined with quercetin/apigenin for senolytic stacks; food sources include parsley, celery, artichoke
How does Luteolin work?: 3',4',5,7-tetrahydroxyflavone; PI3K/AKT/mTOR inhibition; NF-kB suppression; tested as a senolytic adjunct to dasatinib + quercetin; mast-cell stabilizer; weak MAO-B inhibitor

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.