Rankings / Longevity — Senolytics & Polyphenols
Pterostilbene
Longevity · Polyphenol
Tier C
What this is
Paired with NR in EH301 trial — modest ALS functional improvement. Better absorbed than resveratrol in theory but limited direct head-to-head human data. Often combined with nicotinamide riboside (e.g., Basis, Niagen+).
Mechanism
Dimethylated resveratrol analog; better oral bioavailability (~80% vs 1%); SIRT1 activator; AMPK activator; anti-inflammatory
Dose & route
50-250 mg/day
Citations
- https://pubmed.ncbi.nlm.nih.gov/28871885/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5118535/
- https://pubmed.ncbi.nlm.nih.gov/31728050/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.