What does the evidence show about Resveratrol's effects?

Read Off Label rates the evidence for Resveratrol as Weak-Moderate and the benefit magnitude as low-med, producing an overall grade of B- (6.2/10). Oft-cited as foundational longevity compound but human RCTs largely unimpressive.

What safety findings are reported for Resveratrol?

Resveratrol has a low risk profile in the database. Low Legal status: OTC.

What doses or routes are reported for Resveratrol?

150-500 mg/day trans-resveratrol; micronized formulations and co-administration with fat appear in absorption studies This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.

Rankings / Longevity — Senolytics & Polyphenols

Resveratrol

Longevity · Polyphenol

Tier B-

Reviewed by Read Off Label · Last reviewed Jul 11, 2026 · How we grade

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6.2 / 10

Tier B-

Ev 4.5 Bn 3.5 Sf 9

Bottom line

Read Off Label grades Resveratrol as B- (6.2/10) based on weak-moderate evidence, low-med benefit magnitude, and a low-risk safety profile.

Oft-cited as foundational longevity compound but human RCTs largely unimpressive.

Studied, labeled, or reported-use context: 150-500 mg/day trans-resveratrol; micronized formulations and co-administration with fat appear in… — OTC; not individualized guidance.

What the evidence says

Oft-cited as foundational longevity compound but human RCTs largely unimpressive. Poor bioavailability (~1%). Metabolites may be active. 2025 meta-analysis: no significant SIRT1 effect in humans. Popularity persists despite modest signals.

Mechanism

Trans-resveratrol proposed SIRT1 activator (debated — likely indirect); AMPK activation; anti-inflammatory; vascular endothelial effects; poor oral bioavailability

Studied, labeled, or reported dose & route

150-500 mg/day trans-resveratrol; micronized formulations and co-administration with fat appear in absorption studies

This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.

Citations

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Common questions

What does the evidence show about Resveratrol's effects?: Read Off Label rates the evidence for Resveratrol as Weak-Moderate and the benefit magnitude as low-med, producing an overall grade of B- (6.2/10). Oft-cited as foundational longevity compound but human RCTs largely unimpressive.
What safety findings are reported for Resveratrol?: Resveratrol has a low risk profile in the database. Low Legal status: OTC.
What doses or routes are reported for Resveratrol?: 150-500 mg/day trans-resveratrol; micronized formulations and co-administration with fat appear in absorption studies This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
How does Resveratrol work?: Trans-resveratrol proposed SIRT1 activator (debated — likely indirect); AMPK activation; anti-inflammatory; vascular endothelial effects; poor oral bioavailability

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.