Rankings / Longevity — Senolytics & Polyphenols
Resveratrol
Longevity · Polyphenol
Tier B-
Bottom line
Read Off Label grades Resveratrol as B- (6.2/10) based on weak-moderate evidence, low-med benefit magnitude, and a low-risk safety profile.
Oft-cited as foundational longevity compound but human RCTs largely unimpressive.
Typical use: 150-500 mg/day trans-resveratrol; ideally micronized or with fat for absorption — OTC.
What this is
Oft-cited as foundational longevity compound but human RCTs largely unimpressive. Poor bioavailability (~1%). Metabolites may be active. 2025 meta-analysis: no significant SIRT1 effect in humans. Popularity persists despite modest signals.
Mechanism
Trans-resveratrol proposed SIRT1 activator (debated — likely indirect); AMPK activation; anti-inflammatory; vascular endothelial effects; poor oral bioavailability
Dose & route
150-500 mg/day trans-resveratrol; ideally micronized or with fat for absorption
Citations
- https://pubmed.ncbi.nlm.nih.gov/40158656/
- https://www.mdpi.com/1422-0067/25/2/747
- https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2024.1393181/full
- https://pubmed.ncbi.nlm.nih.gov/41893010/
- https://pubmed.ncbi.nlm.nih.gov/41901130/
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Common questions
- Does Resveratrol work?
- Read Off Label rates the evidence for Resveratrol as Weak-Moderate and the benefit magnitude as low-med, producing an overall grade of B- (6.2/10). Oft-cited as foundational longevity compound but human RCTs largely unimpressive.
- Is Resveratrol safe?
- Resveratrol has a low risk profile in published human data. Legal status: OTC. This is not medical advice — see the disclaimer.
- What is the typical dose for Resveratrol?
- 150-500 mg/day trans-resveratrol; ideally micronized or with fat for absorption
- How does Resveratrol work?
- Trans-resveratrol proposed SIRT1 activator (debated — likely indirect); AMPK activation; anti-inflammatory; vascular endothelial effects; poor oral bioavailability
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.