Rankings / Longevity — Senolytics & Polyphenols
Fisetin
Longevity · Senolytic / polyphenol
Tier B-
Bottom line
Read Off Label grades Fisetin as B- (6.2/10) based on preclinical-moderate evidence, variable benefit magnitude, and a low-risk safety profile.
Yousefzadeh 2018 demonstrated senolytic activity in naturally aged mice.
Typical use: 20 mg/kg for 2 consecutive days monthly ("hit and run"); or daily low-dose — OTC.
What this is
Yousefzadeh 2018 demonstrated senolytic activity in naturally aged mice. Mayo Clinic AFFIRM-LITE and AFFIRM trials in frailty and COVID. Safer profile than dasatinib; preferred entry-point for DIY senolytic protocols.
Mechanism
Flavonol; more potent senolytic than quercetin in preclinical assays; also inhibits mTOR; PI3K/AKT modulation; anti-inflammatory and antioxidant
Dose & route
20 mg/kg for 2 consecutive days monthly ("hit and run"); or daily low-dose
Citations
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6197652/
- https://clinicaltrials.gov/study/NCT03675724
- https://www.ebiomedicine.com/article/S2352-3964(18)30373-6/fulltext
- https://pubmed.ncbi.nlm.nih.gov/41683217/
- https://pubmed.ncbi.nlm.nih.gov/40994903/
- https://pubmed.ncbi.nlm.nih.gov/41831318/
- https://pubmed.ncbi.nlm.nih.gov/41350483/
- https://doi.org/10.1007/s12016-026-09164-4
- https://doi.org/10.1007/s10238-026-02166-8
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Common questions
- Does Fisetin work?
- Read Off Label rates the evidence for Fisetin as Preclinical-Moderate and the benefit magnitude as variable, producing an overall grade of B- (6.2/10). Yousefzadeh 2018 demonstrated senolytic activity in naturally aged mice.
- Is Fisetin safe?
- Fisetin has a low risk profile in published human data. Legal status: OTC. This is not medical advice — see the disclaimer.
- What is the typical dose for Fisetin?
- 20 mg/kg for 2 consecutive days monthly ("hit and run"); or daily low-dose
- How does Fisetin work?
- Flavonol; more potent senolytic than quercetin in preclinical assays; also inhibits mTOR; PI3K/AKT modulation; anti-inflammatory and antioxidant
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.