Rankings / Longevity — Senolytics & Polyphenols
Fisetin
Longevity · Senolytic / polyphenol
Tier B-
What this is
Yousefzadeh 2018 demonstrated senolytic activity in naturally aged mice. Mayo Clinic AFFIRM-LITE and AFFIRM trials in frailty and COVID. Safer profile than dasatinib; preferred entry-point for DIY senolytic protocols.
Mechanism
Flavonol; more potent senolytic than quercetin in preclinical assays; also inhibits mTOR; PI3K/AKT modulation; anti-inflammatory and antioxidant
Dose & route
20 mg/kg for 2 consecutive days monthly ("hit and run"); or daily low-dose
Citations
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6197652/
- https://clinicaltrials.gov/study/NCT03675724
- https://www.ebiomedicine.com/article/S2352-3964(18)30373-6/fulltext
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