Rankings / Longevity — Senolytics & Polyphenols
Senolytics (D+Q combo)
Longevity · Senolytic
Tier C+
What this is
First-ever senolytic human trials (Justice 2019, Hickson 2019). Reduced senescent cell markers in adipose tissue; improved physical function in IPF. Epigenetic clock data mixed. Long-term safety in healthy adults unknown.
Mechanism
Dasatinib (BCR-ABL/Src inhibitor) + Quercetin (flavonoid) selectively kill senescent cells by disabling pro-survival SCAP pathways; cleared SnCs reduce SASP inflammation
Dose & route
D 100 mg + Q 1000 mg x 2-3 consecutive days, then 2-4 weeks off (intermittent "hit-and-run"); multiple cycles
Citations
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6796530/
- https://www.ebiomedicine.com/article/S2352-3964(19)30641-3/fulltext
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10929829/
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