Rankings / CV/Lipid
Cardiovascular & Lipids
Statins, PCSK9 inhibitors, niacin, bergamot, EPA esters, and the rest of the lipid-lowering toolkit — prescription and OTC. Outcome evidence is among the strongest on the site.
| # | Compound | Ev | Bn | Sf | Grade · Score |
|---|---|---|---|---|---|
| 1 | Rosuvastatin / atorvastatin (statins) HMG-CoA reductase inhibitor | 10.0 | 10.0 | 7.0 | A+ 8.9 |
| 2 | PCSK9 inhibitors (evolocumab / alirocumab / inclisiran) Monoclonal antibody or siRNA | 8.0 | 10.0 | 9.0 | A 8.6 |
| 3 | Lp(a)-lowering therapies (olpasiran / pelacarsen / lepodisiran / zerlasiran / muvalaplin) RNA-targeted or small-molecule Lp(a) lowering | 8.0 | 10.0 | 7.0 | A- 7.9 |
| 4 | Icosapent ethyl (Vascepa) Purified EPA ester | 8.0 | 8.0 | 7.0 | A- 7.6 |
| 5 | Aspirin (low-dose) Irreversible COX-1 inhibitor | 8.0 | 8.0 | 5.0 | B+ 7.5 |
| 6 | Ezetimibe NPC1L1 inhibitor | 8.0 | 5.0 | 10.0 | B+ 7.4 |
| 7 | Obicetrapib CETP inhibitor (next-generation) | 8.0 | 8.0 | 7.0 | B+ 7.4 |
| 8 | Citrus bergamot Polyphenol extract | 6.0 | 5.0 | 9.0 | B 6.9 |
| 9 | Coenzyme Q10 (ubiquinone/ubiquinol) Electron transport cofactor | 6.0 | 3.5 | 10.0 | B 6.8 |
| 10 | Garlic extract (aged / allicin) Organosulfur polyphenol | 6.0 | 3.5 | 9.0 | B 6.5 |
| 11 | Berberine AMPK activator / natural | 6.0 | 5.0 | 7.0 | B 6.4 |
| 12 | Niacin (nicotinic acid) B3 / lipid modifier | 8.0 | 5.0 | 3.5 | B- 5.9 |
| 13 | Red yeast rice Natural monacolin K source | 6.0 | 5.0 | 5.0 | B- 5.9 |
| 14 | Bempedoic acid ACL inhibitor | 7.0 | 5.0 | 5.0 | C+ 5.7 |
| 15 | Nattokinase Fibrinolytic enzyme | 3.0 | 5.0 | 7.0 | C+ 5.2 |