Rankings / Longevity — Supplements
Alpha-ketoglutarate (Ca-AKG)
Longevity · TCA cycle intermediate
Tier B
What this is
Shahmirzadi 2020 Cell Metab: ~12% lifespan extension in mice started at 18 mo. Retrospective TruAge study: ~8-year reduction in epigenetic age after ~7 months of Rejuvant. ABLE RCT ongoing. Better human data than most experimental compounds.
Mechanism
Krebs cycle metabolite; epigenetic regulator via TET/JHDM demethylases; substrate for collagen synthesis; nitrogen metabolism; declines ~10x from age 40-80
Dose & route
1-2 g/day sustained-release Ca-AKG
Citations
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8508957/
- https://www.aging-us.com/article/203736/text
- https://link.springer.com/article/10.1007/s11357-023-00813-6
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.