Rankings / Longevity — Supplements
NAD+ / NMN / NR
Longevity · NAD+ precursor
Tier B
What this is
Yoshino 2021: NMN 250 mg/day improved muscle insulin sensitivity 25% in prediabetic women. Multiple RCTs show elevated NAD+ but inconsistent functional outcomes (strength, cognition, CV markers). Boosting NAD+ is easy; demonstrating clinical benefit is not.
Mechanism
Precursors to NAD+ — essential cofactor for sirtuins (SIRT1-7), PARPs, CD38; ETC; cellular NAD+ declines with age
Dose & route
250-1000 mg/day NMN or NR (sublingual or oral); IV NAD+ infusions also used
Citations
- https://www.science.org/doi/10.1126/science.abe9985
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10721522/
- https://www.nature.com/articles/s41598-023-29787-3
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.