Rankings / Longevity — Supplements
NAD+ / NMN / NR
Longevity · NAD+ precursor
Also known as: Nicotinamide mononucleotide ·Nicotinamide riboside ·Niagen
Tier B+
Bottom line
Read Off Label grades NAD+ / NMN / NR as B+ (7.1/10) based on moderate evidence, variable benefit magnitude, and a low-risk safety profile.
Yoshino 2021: NMN 250 mg/day improved muscle insulin sensitivity 25% in prediabetic women.
Typical use: 250-1000 mg/day NMN or NR (sublingual or oral); IV NAD+ infusions also used — OTC.
What this is
Yoshino 2021: NMN 250 mg/day improved muscle insulin sensitivity 25% in prediabetic women. Multiple RCTs show elevated NAD+ but inconsistent functional outcomes (strength, cognition, CV markers). Boosting NAD+ is easy; demonstrating clinical benefit is not.
Mechanism
Precursors to NAD+ — essential cofactor for sirtuins (SIRT1-7), PARPs, CD38; ETC; cellular NAD+ declines with age
Dose & route
250-1000 mg/day NMN or NR (sublingual or oral); IV NAD+ infusions also used
Citations
- https://www.science.org/doi/10.1126/science.abe9985
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10721522/
- https://www.nature.com/articles/s41598-023-29787-3
- https://doi.org/10.1172/jci198031
- https://pubmed.ncbi.nlm.nih.gov/40799515/
- https://doi.org/10.25259/csdm_6_2026
- https://doi.org/10.1002/alz.71360
- https://pubmed.ncbi.nlm.nih.gov/41256733/
- https://pubmed.ncbi.nlm.nih.gov/39157755/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does NAD+ / NMN / NR work?
- Read Off Label rates the evidence for NAD+ / NMN / NR as Moderate and the benefit magnitude as variable, producing an overall grade of B+ (7.1/10). Yoshino 2021: NMN 250 mg/day improved muscle insulin sensitivity 25% in prediabetic women.
- Is NAD+ / NMN / NR safe?
- NAD+ / NMN / NR has a low risk profile in published human data. Legal status: OTC. This is not medical advice — see the disclaimer.
- What is the typical dose for NAD+ / NMN / NR?
- 250-1000 mg/day NMN or NR (sublingual or oral); IV NAD+ infusions also used
- How does NAD+ / NMN / NR work?
- Precursors to NAD+ — essential cofactor for sirtuins (SIRT1-7), PARPs, CD38; ETC; cellular NAD+ declines with age
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.