Rankings / Longevity — Supplements
Sulforaphane
Longevity · Nrf2 activator
Tier B
What this is
Solid Nrf2 pathway activation. Clinical data includes autism improvement (Singh 2014), reduced airborne carcinogen excretion in Qidong (Kensler 2014), and various metabolic markers. Highly unstable — preformed sulforaphane or myrosinase co-delivery critical.
Mechanism
Isothiocyanate from broccoli sprouts; activates Nrf2-ARE pathway — upregulates phase II detoxification and antioxidant enzymes; HDAC inhibitor; autophagy inducer
Dose & route
10-40 mg sulforaphane equivalent/day; broccoli sprouts or Avmacol/Prostaphane
Citations
- https://pubmed.ncbi.nlm.nih.gov/24912588/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4130664/
- https://www.mdpi.com/2072-6643/12/6/1794
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.