Rankings / Longevity — Supplements
Glycine + NAC (GlyNAC)
Longevity · Amino acid combo
Tier B
What this is
Kumar/Sekhar Baylor team showed 16-week GlyNAC supplementation in older adults improved oxidative stress, mitochondrial function, insulin resistance, grip strength, gait speed, and inflammatory markers. Notable for direct functional endpoints.
Mechanism
Combined glycine + NAC replenishes glutathione (primary intracellular antioxidant); improves mitochondrial function; reduces oxidative stress and genotoxicity; shown to reverse multiple hallmarks of aging in older adults
Dose & route
Glycine 100 mg/kg + NAC 100 mg/kg daily (Kumar/Sekhar protocol)
Citations
- https://pubmed.ncbi.nlm.nih.gov/33876242/
- https://pubmed.ncbi.nlm.nih.gov/34746943/
- https://academic.oup.com/biomedgerontology/article/78/1/75/6624702
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.