Rankings / Longevity — Supplements
17-alpha estradiol
Longevity · Non-feminizing estrogen
Tier C-
Bottom line
Read Off Label grades 17-alpha estradiol as C- (4.5/10) based on preclinical evidence, variable benefit magnitude, and a low-med-risk safety profile.
ITP: significant male mouse lifespan extension at multiple doses; no female effect (Strong 2016).
Typical use: No established human dosing — Research chemical / compounded.
What this is
ITP: significant male mouse lifespan extension at multiple doses; no female effect (Strong 2016). Unique in separating metabolic benefits of estrogens from feminization. Harrison lab ongoing work. Very limited human data.
Mechanism
Stereoisomer of 17β-estradiol with minimal ERα binding; non-feminizing; activates mTORC2 (not mTORC1); improves metabolic markers in males
Dose & route
No established human dosing
Citations
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4844151/
- https://onlinelibrary.wiley.com/doi/10.1111/acel.12496
- https://www.nia.nih.gov/news/diabetes-drug-increases-lifespan-male-mice-shows-smaller-effect-females
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does 17-alpha estradiol work?
- Read Off Label rates the evidence for 17-alpha estradiol as Preclinical and the benefit magnitude as variable, producing an overall grade of C- (4.5/10). ITP: significant male mouse lifespan extension at multiple doses; no female effect (Strong 2016).
- Is 17-alpha estradiol safe?
- 17-alpha estradiol has a low-med risk profile in published human data. Legal status: Research chemical / compounded. This is not medical advice — see the disclaimer.
- What is the typical dose for 17-alpha estradiol?
- No established human dosing
- How does 17-alpha estradiol work?
- Stereoisomer of 17β-estradiol with minimal ERα binding; non-feminizing; activates mTORC2 (not mTORC1); improves metabolic markers in males
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.