Rankings / Longevity — Supplements
GDF11
Longevity · Circulating factor
Tier D+
What this is
Loffredo 2013 Cell reported anti-aging cardiac effects; follow-up work disputed specificity and found GDF11 indistinguishable from myostatin (GDF8) using older reagents. Field is unsettled.
Mechanism
TGF-β superfamily growth differentiation factor; parabiosis experiments suggested rejuvenating effects on heart, brain, muscle — contested and partially retracted; may improve cerebral vasculature
Dose & route
No established clinical dose
Citations
- https://www.cell.com/cell/fulltext/S0092-8674(13)00456-X
- https://www.nature.com/articles/s41598-017-11435-2
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4508975/
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