Rankings / Longevity — Supplements
Klotho
Longevity · Anti-aging protein
Tier D+
Bottom line
Read Off Label grades Klotho as D+ (3.7/10) based on preclinical evidence, variable benefit magnitude, and a med-risk safety profile.
Kuro-o's original mouse models showed dramatic acceleration of aging in knockouts.
Typical use: No established clinical dosing — Experimental.
What this is
Kuro-o's original mouse models showed dramatic acceleration of aging in knockouts. KLOTHO variants (VS haplotype) associated with longer lifespan in humans. Klotho Therapeutics and others developing; no clinical-stage longevity drug yet.
Mechanism
Transmembrane protein; co-receptor for FGF23; extracellular domain acts as hormone; deficiency causes accelerated aging phenotype; overexpression extends lifespan in mice
Dose & route
No established clinical dosing
Citations
- https://www.nature.com/articles/36285
- https://www.cell.com/cell-reports/fulltext/S2211-1247(17)31242-9
- https://pubmed.ncbi.nlm.nih.gov/17855559/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Klotho work?
- Read Off Label rates the evidence for Klotho as Preclinical and the benefit magnitude as variable, producing an overall grade of D+ (3.7/10). Kuro-o's original mouse models showed dramatic acceleration of aging in knockouts.
- Is Klotho safe?
- Klotho has a med risk profile in published human data. Legal status: Experimental. This is not medical advice — see the disclaimer.
- What is the typical dose for Klotho?
- No established clinical dosing
- How does Klotho work?
- Transmembrane protein; co-receptor for FGF23; extracellular domain acts as hormone; deficiency causes accelerated aging phenotype; overexpression extends lifespan in mice
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.