Rankings / Longevity — Supplements
Klotho
Longevity · Anti-aging protein
Tier D+
What this is
Kuro-o's original mouse models showed dramatic acceleration of aging in knockouts. KLOTHO variants (VS haplotype) associated with longer lifespan in humans. Klotho Therapeutics and others developing; no clinical-stage longevity drug yet.
Mechanism
Transmembrane protein; co-receptor for FGF23; extracellular domain acts as hormone; deficiency causes accelerated aging phenotype; overexpression extends lifespan in mice
Dose & route
No established clinical dosing
Citations
- https://www.nature.com/articles/36285
- https://www.cell.com/cell-reports/fulltext/S2211-1247(17)31242-9
- https://pubmed.ncbi.nlm.nih.gov/17855559/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.