Rankings / Longevity — Supplements
Lithium (microdose)
Longevity · Alkali metal (trace)
Tier B
What this is
Zarse 2011: small Japanese village study found higher drinking water lithium associated with reduced all-cause mortality. Multiple ecological studies link trace lithium to lower suicide rates. Strongest biomarker: reduced dementia risk.
Mechanism
At microdoses: GSK-3β inhibition; neuroprotection; mood stabilization; may upregulate BDNF; autophagy modulation; reduced neurodegeneration markers
Dose & route
1-10 mg elemental lithium as orotate/aspartate (microdose); 300-1200 mg lithium carbonate Rx
Citations
- https://pubmed.ncbi.nlm.nih.gov/21301380/
- https://www.bmj.com/content/342/bmj.d1253
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4150431/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.