Rankings / Longevity — Supplements
Plasma exchange / young plasma
Longevity · Dilutional therapeutic
Tier D
Bottom line
Read Off Label grades Plasma exchange / young plasma as D (3.3/10) based on weak evidence, low-med benefit magnitude, and a med-high-risk safety profile.
Conboy lab 2020 showed neutral saline + albumin exchange had rejuvenating effects similar to young plasma — pointing to a dilution mechanism, not 'youth factors.
Typical use: Clinical TPE protocols — weekly for several sessions — Research/clinical setting.
What this is
Conboy lab 2020 showed neutral saline + albumin exchange had rejuvenating effects similar to young plasma — pointing to a dilution mechanism, not 'youth factors.' FDA 2019 warned against Ambrosia-style young-plasma transfusions for anti-aging. New human data: a single-blinded, placebo-controlled RCT (Fuentealba/Kiprov, Aging Cell 2025, n=42) found repeated therapeutic plasma exchange (TPE) lowered biological-age clocks — roughly 1.3 years with TPE alone and 2.6 years with TPE+IVIG — with an acceptable safety profile (2 AEs requiring discontinuation). A May 2026 preprint (Lauc/GlycanAge, n=20,405 across 42 studies) validated the IgG N-glycome as a modifiable biological-age biomarker and ranked TPE the largest per-month reducer (HRT and caloric restriction also lowered it) — preprint, not yet peer-reviewed. Evidence remains small-N on surrogate clocks, not hard outcomes; TPE is invasive, costly, and clinic-only.
Mechanism
Therapeutic plasma exchange (TPE) removes pro-aging factors (dilution of 'bad' blood) OR replaces with young plasma; Conboy lab shows dilution alone may be sufficient
Dose & route
Clinical TPE protocols — weekly for several sessions
Citations
- https://www.aging-us.com/article/103418/text
- https://doi.org/10.1111/acel.70103
- https://www.fda.gov/consumers/consumer-updates/younger-blood-does-not-make-you-younger-or-healthier
- https://pubmed.ncbi.nlm.nih.gov/30022616/
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Common questions
- Does Plasma exchange / young plasma work?
- Read Off Label rates the evidence for Plasma exchange / young plasma as Weak and the benefit magnitude as low-med, producing an overall grade of D (3.3/10). Conboy lab 2020 showed neutral saline + albumin exchange had rejuvenating effects similar to young plasma — pointing to a dilution mechanism, not 'youth factors.
- Is Plasma exchange / young plasma safe?
- Plasma exchange / young plasma has a med-high risk profile in published human data. Legal status: Research/clinical setting. This is not medical advice — see the disclaimer.
- What is the typical dose for Plasma exchange / young plasma?
- Clinical TPE protocols — weekly for several sessions
- How does Plasma exchange / young plasma work?
- Therapeutic plasma exchange (TPE) removes pro-aging factors (dilution of 'bad' blood) OR replaces with young plasma; Conboy lab shows dilution alone may be sufficient
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.