Rankings / Longevity — Supplements
Yamanaka factors / partial reprogramming
Longevity · Epigenetic reprogramming
Tier D+
What this is
Ocampo 2016 Cell and subsequent Belmonte work show rejuvenation of aged tissues in mice via cyclic OSK expression. Altos Labs ($3B+ funding) actively developing clinical protocols. No approved human therapy yet.
Mechanism
Transient expression of OCT4, SOX2, KLF4, MYC (or OSK without MYC) resets epigenetic age markers without inducing pluripotency; research-stage approach to reverse cellular aging
Dose & route
No approved human protocol
Citations
- https://www.cell.com/cell/fulltext/S0092-8674(16)31664-6
- https://www.nature.com/articles/s43587-022-00280-2
- https://www.nature.com/articles/d41586-022-00180-w
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