Rankings / Toxins

Toxins

Air, water, food, and lifestyle exposures with evidence for harm. Everything here scores poorly by design — the "intervention" is reducing exposure.

Compounds ranked
40
# Compound Class Ev Mag Prev Priority · Score
1 Chronic sleep deprivation
Lifestyle
Lifestyle exposure 10 10 10 CRITICAL 10
2 Loneliness / social isolation
Lifestyle
Lifestyle exposure 10 10 10 CRITICAL 10
3 Sedentary behavior / sitting
Lifestyle
Lifestyle exposure 10 10 10 CRITICAL 10
4 Tobacco smoke (direct / secondhand)
Combustion complex
Lifestyle exposure 10 10 10 CRITICAL 10
5 Lead
Heavy metal / neurotoxicant
Heavy metal 10 10 8 CRITICAL 9.4
6 PM2.5 (fine particulate matter)
Air pollution
Air pollutant 10 10 8 CRITICAL 9.4
7 PFAS (PFOA / PFOS / GenX)
Forever chemicals
Endocrine disruptor 8 10 8 CRITICAL 8.8
8 Benzene
Volatile organic compound
Air pollutant 10 8 8 CRITICAL 8.6
9 Chronic psychological stress
Lifestyle
Lifestyle exposure 8 8 10 CRITICAL 8.6
10 Nitrite poppers (amyl/isobutyl nitrite products)
Recreational inhalant / vasodilator
Recreational inhalant 8 8 10 CRITICAL 8.6
11 Yellow oleander-adulterated weight-loss supplements
Botanical adulterant / cardiac glycoside
Supplement adulterant 8 8 10 CRITICAL 8.6
12 Alcohol (ethanol)
Neurotoxic psychoactive
Lifestyle exposure 10 10 5 CRITICAL 8.5
13 Radon
Radioactive gas
Air pollutant 10 10 5 CRITICAL 8.5
14 DMAA / DMHA stimulant adulterants
Illicit stimulant adulterant
Supplement adulterant 8 8 8 HIGH 8
15 Formaldehyde
VOC / IARC Group 1
Air pollutant 8 8 8 HIGH 8
16 Nitrous oxide (recreational inhalation)
Recreational inhalant / dissociative gas
Recreational inhalant 8 8 8 HIGH 8
17 Organophosphate pesticides (chlorpyrifos / malathion)
Acetylcholinesterase inhibitor
Pesticide 8 8 8 HIGH 8
18 TCE (trichloroethylene)
Chlorinated solvent
Air pollutant 8 8 8 HIGH 8
19 NO2 (nitrogen dioxide)
Air pollution
Air pollutant 8 8 6.5 HIGH 7.6
20 Ozone (tropospheric)
Air pollution
Air pollutant 8 8 6.5 HIGH 7.6
21 Aflatoxins
Mycotoxin
Mycotoxin 10 10 1 HIGH 7.3
22 Arsenic
Metalloid / IARC Group 1
Heavy metal 8 8 5 HIGH 7.1
23 Phthalates (DEHP / DBP / BBP / DEP)
Endocrine disruptor
Endocrine disruptor 7 6.5 5 MODERATE 6.2
24 Fluoride (high-dose)
Controversial
Water contaminant 8 8 1 MODERATE 5.9
25 Mercury (methylmercury)
Heavy metal / neurotoxicant
Heavy metal 8 5 5 MODERATE 5.9
26 Blue light (evening artificial light at night)
Circadian disruptor
Lifestyle exposure 8 5 3 MODERATE 5.3
27 Cadmium
Heavy metal / nephrotoxicant
Heavy metal 8 5 3 MODERATE 5.3
28 PAHs (polycyclic aromatic hydrocarbons — grilled meats, air)
Combustion carcinogen
Cooking byproduct 8 5 3 MODERATE 5.3
29 PBDEs (polybrominated diphenyl ethers)
Flame retardant
Endocrine disruptor 8 5 3 MODERATE 5.3
30 Neonicotinoids (imidacloprid / clothianidin)
Neurotoxic insecticide
Pesticide 8 5 1 MODERATE 4.7
31 Acrylamide (high-heat cooking)
Maillard byproduct
Cooking byproduct 6 3.5 5 MODERATE 4.7
32 BPA / BPS / BPF (bisphenols)
Endocrine disruptor
Endocrine disruptor 6 5 3 MODERATE 4.7
33 DBPs (disinfection byproducts — trihalomethanes, haloacetic acids)
Chlorination byproducts
Endocrine disruptor 6 3.5 3 MODERATE 4.1
34 Ochratoxin A
Mycotoxin
Mycotoxin 6 3.5 3 MODERATE 4.1
35 Triclosan / triclocarban
Antimicrobial
Endocrine disruptor 6 3.5 3 MODERATE 4.1
36 EMF / RF exposure (cell phones, Wi-Fi)
Non-ionizing radiation
Lifestyle exposure 4.5 4 3 LOW 3.9
37 Glyphosate (Roundup)
Broad-spectrum herbicide
Pesticide 3 5 3 LOW 3.8
38 Parabens (methyl / propyl / butyl)
Preservative / weak estrogen
Endocrine disruptor 4.5 3.5 3 LOW 3.7
39 Microplastics / nanoplastics
Emerging contaminant
Water contaminant 3 4 3 LOW 3.4
40 Aluminum
Widespread metal
Heavy metal 4.5 3.5 1 LOW 3.1

This category inverts the rest of the site. Instead of "what to add," it ranks "what to reduce," scored by avoidance priority — a blend of how much harm an exposure does, how strong the evidence is, and how common it is. Everything here scores poorly by design; the number tells you how much an exposure is worth your attention to avoid, not whether it is "good."

The unglamorous top of the list

The highest-priority exposures are the ones people underrate because they are familiar. Tobacco smoke, excess alcohol, chronic sleep deprivation, a sedentary lifestyle, and social isolation all sit at or near the top, backed by enormous bodies of evidence. They are far less exciting than microplastics — and they matter much more.

Real environmental hazards

Air pollution (PM2.5), lead, radon, PFAS, and benzene are genuine, well-evidenced harms worth engineering out of your environment — air filtration, water testing, radon testing. This is the corner of the database that rewards practical changes to your surroundings more than anything you can swallow.

Where the worry outruns the evidence

Some popular fears — EMF and RF from phones and Wi-Fi, evening blue light, acrylamide from cooking — rank lower here because either the harm magnitude or the human evidence is weaker than the headlines suggest. That is not "harmless"; it is "lower priority than the things above." Spend your avoidance energy where the score says it actually pays off.

Frequently asked

What is the most important toxin to avoid?

The familiar ones top the list: tobacco smoke, excess alcohol, chronic sleep deprivation, sedentary behaviour, and social isolation. They are backed by the strongest evidence and the highest prevalence, which is why they outrank trendier environmental fears.

How worried should I be about microplastics or EMF?

Less than the headlines imply, relative to the basics. These rank lower on avoidance priority because the harm magnitude or the human evidence is weaker than for air pollution, lead, or lifestyle factors. Worth watching, not worth panic.

How is the toxins ranking scored?

By avoidance priority — a blend of harm magnitude, strength of evidence, and how common the exposure is. It is a separate scale from the benefit-based rankings, because the intervention here is reducing exposure rather than adding a compound.

Scores reflect the published evidence, not a recommendation to use any compound or protocol. Nothing here is medical advice. How we score →

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